Sequence alignment algorithms form the foundation of comparative genomics, structural biology and evolutionary studies by identifying regions of similarity among nucleotide or protein sequences.

Open-access databases such as the European Nucleotide Archive (ENA) contain more than 2.4 million bacterial genomes, and this number continues to grow rapidly. Until now, searching these vast ...

This illustration demonstrates how metapipeline-DNA processes raw genome sequencing data. It begins by aligning the sequence of DNA base pairs to a reference genome. Then produces sets of detected ...

April 14, 2025 – Genome Research (https://genome.org) publishes a second special issue highlighting advances in long-read sequencing applications in biology and medicine. In this second Special Issue, ...

Haoyu Cheng, Ph.D., assistant professor of biomedical informatics and data science at Yale School of Medicine, has developed a new algorithm capable of building complete human genomes using standard ...

SAVANA uses a machine learning algorithm to identify cancer-specific structural variations and copy number aberrations in long-read DNA sequencing data. The complex structure of cancer genomes means ...

Scaffolded DNA and RNA origami is a technique that allows scientists to build tiny, highly precise two- and three-dimensional objects. Because these nanostructures can interact naturally with ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...